This document provides a framework and practical example for developing a basin-scale water resources development strategy, using the case of the Kamala River Basin in Nepal. The strategy, developed through a collaborative process between the governments of Nepal and Australia over 5 years, aims to enable the sustainable management of water resources to improve the wellbeing of the basin’s population and environment. Reflecting Nepal’s new constitutional focus on basin-level water planning, the document outlines the process undertaken to create the Kamala River Basin WRD strategy, offering a template that can be applied to develop similar strategies in other river basins across Nepal.